Horizon 21 Consortium

Investigating Alzheimer's disease linked to trisomy 21

Horizon 21 research centers all over Europe

The Horizon 21 programme currently brings together 11 teams from different european research sites, led by clinical researchers.
The programme develops collaborations with other clinicians, inside and outside Europe.

Horizon 21 research centers all over Europe

Horizon 21 research centres all over Europe

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Consortium issues

Detecting early changes related to Alzheimer’s disease in adults with Down syndrome can be difficult due to the presence of intellectual disability and other health issues.

The diagnosis of Alzheimer’s disease in persons with Down syndrome requires appropriate evaluation tools and a specialized team with significant experience.
In order to conduct research projects, the investigating centers need to work hand in hand and harmonize their protocols so that data can be compared and combined.
This consortium also collaborates with other research centers all over the world.


  • Harmonizing diagnosis procedures (in clinical investigations, neuropsychology, biochemistry, blood and CSF, imaging)
  • Defining common criteria for diagnosis of Alzheimer’s disease
  • Diversificating and multiplicating studies thanks to the sharing of expertises : cognitive evaluation, clinical evaluation, identification of biomarkers in biochemistry, genetics and imaging
  • Developing publications and network

–> For a unique european cohort (over 1 000 patients) in order to develop clinical trials.